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This service is more advanced with JavaScript available, learn more at http: Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity.

As this book addresses this difficult disease, it accomplishes three plder goals. First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck SCCHNsand how these factors affect prognosis.

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Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus HPV infection. These two broad classes of SCCHN have significant differences hpsting disease profile and response to treatment, as we discuss.

Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.

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Molecular Determinants of Head and Neck Cancer. Front Matter Pages i-ix.

The Pathobiology of Head and Neck Cancer. Pages Variant Strains, Discrete Protein Function.

Full text of "Town Topics (Princeton), Apr. 09, "

Hanqing Liu, Jennifer R. Cracchiolo, Tim N. Beck, Ilya G.

Serebriiskii, Erica A. Tanguy Y. Seiwert, Tim N.

Beck, Ravi Salgia. Bhavana S.

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Vangara, Jennifer R. Hypoxia and Radioresistance in Head and Neck Cancer. Sequencing HNC: Emergence of Notch Signaling.

Curtis R. Pickering, Thomas J. Ow, Jeffrey N.

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Gene Expression in HNC. Back Matter Pages About this book Introduction Head and neck bung, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world.

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Dna repair Human Papillomavirus genomics head and neck cancer hypoxia molecular determinants. Editors and affiliations.

Golemis 2 1. Bibliographic information DOI https: Buy options.